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Rudolph Virchow (1821-1902) was a leading figure in the medical, political and intellectual life of Germany in the second half of the nineteenth century. He became the most famous pathologist of his time, especially through his book "Cellular Pathology" – which discussed pathology in terms of the functioning of the cells in the anatomic lesions of diseases. Virchow's writings were voluminous: he wrote many books and more than 2, 000 articles ...

In 1890, just a few years after the discovery of the chromosomes, David Paul Hansemann, a pathologist-in-training with the famous Rudolph Virchow in Berlin, produced a theory of the pathogenesis of cancer involving the key current concept: that the first change which occurs in cancer is an alteration of the hereditary material of a normal cell at the site where the cancerous process begins. In the process of linking cancer to chromosomal mater...