15 Ergebnisse.

Starch - Evolution and Recent Advances is about the historical, scientific, and technological journey of starch so far, taking into account its traditional roles, uses, and applications as well as the most recent advances in the study of this unique polymer. It is a collective endeavor by a group of editors and authors with a wealth of experience and expertise in research and development, teaching, and quality control and public health. Chapte...

The book explores distinct aspects of protein purification and characterization steps. It discusses solubility problems, resin selection tricks, and essential credentials in a purification process. In addition, the book examines aggregation and proteinopathy-related protein detection methods and reviews several essential protein detection and characterization methods in cancer for diagnosis, prognosis, and therapy, such as enzyme-linked immuno...

Over the years, natural products such as essential oils have been gaining more and more prominence due to their perceived health benefits. Plants rich in essential oils represent a viable source of biomolecules for use in the most varied human activities, such as agricultural, cosmetic, and pharmaceutical applications. Essential oils are natural volatile fractions extracted from aromatic plants that are formed by classes of substances such as ...

Epigenetics, which deals with the study of heritable gene expression that takes place independent of changes in DNA sequence, and optogenetics, which deals with the study of genes expressed under the influence of light, are two emerging areas of study and research that have contributed immensely to our current knowledge of mechanisms and disease processes in humans. These disciplines are interrelated in the broader picture of biology and one c...

Cell culture is cell cloning technology that simulates in vivo environment conditions such as asepsis, appropriate temperature, and pH as well as certain nutritional conditions to enable cells to survive, grow, reproduce, and maintain their structure and function. Cell culture can be used to grow human, animal, plant, and microbial cells. Each type of cell culture has its own characteristics and essential conditions. This book focuses on the a...

This book gives a current review of the links between the structure and function of hydrolases and ligases, as well as ideas for better using these critical enzymes. The book is split into two sections: ¿Cleavage¿ and ¿Ligases.¿ These enzymes are the biggest and most varied family of enzymes, allowing researchers to investigate the structural variety that underpins their different biological roles. In light of recent scientific advances, there...

The term "reactive oxygen species" (ROS) refers to a group of reactive molecules and free radicals produced by molecular oxygen. In recent decades, there has been great interest in the role of ROS in various diseases. From basic science research to clinical trials, biomedical scientists have made rapid progress toward a better understanding of ROS-metabolizing systems and their role in health and diseases. This book includes sixteen chapters t...

Vitamin K is a fat-soluble vitamin and a significant hydrophobic signaling molecule, like vitamins A and D. Besides its classical functions as a cofactor of ¿-glutamyl carboxylase, which catalyzes the ¿-carboxylation of vitamin K-dependent proteins, vitamin K has novel physiological and pharmacological activities that have been elucidated in the past two decades. The discovery of detailed action mechanisms of non-classical activities of vitami...

Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer presents recent advances in understanding the roles of fibroblasts and mesenchymal stem cells in tissue homeostasis and the development of human disease. The book delves into general principles of fibroblast and mesenchymal stem cell biology and their diversity across the human body. It highlights these cells' unique and shared characteristics across organs (e.g., vasculature, kid...

Understanding extracellular matrix (ECM) structure and function is important for developing biomedical applications that are as close to 'native' as possible. Written by pioneering scientists from all over the world, this book reports research and new developments in the field of collagen structure, function, and biomechanics and discusses the relevance of hyaluronic acid and its therapeutic uses. It gives readers a glimpse of what is current ...

Vitamin E is a group of fat-soluble compounds found in a wide variety of foods. Daily requirements of vitamin E can be met with a balanced diet. High-dose supplementation may be hazardous rather than beneficial. Vitamin E serves as an antioxidant, participates in anti-inflammatory processes, inhibits platelet aggregation, and enhances immunity. Vitamin E supplementation can be beneficial against coronary artery disease, eye disorders, cognitiv...

For the past two decades, the protein kinase family has been an intense area of research for developing anticancer drugs. Despite tremendous advancements in kinase drug expansion, many kinases are still unexplored. As such, this book includes research and review articles from experts that focus on protein kinase signalling pathways as a molecular drug target. Chapters include illustrations and cover such topics as the mechanism of action and a...

The recent breakthrough in microbial studies has applied next-generation sequencing (NGS), a massive omics analysis, to the composition and structure of microbial communities. NGS can identify microbes without the need for their cultivation. Their mere presence can be ascertained and often quantitated, and even their metabolic capabilities of microbial constituents predicted. This breakthrough led to an explosive growth in research on microbes...

Transcriptome analysis is the study of the transcriptome, of the complete set of RNA transcripts that are produced under specific circumstances, using high-throughput methods. Transcription profiling, which follows total changes in the behavior of a cell, is used throughout diverse areas of biomedical research, including diagnosis of disease, biomarker discovery, risk assessment of new drugs or environmental chemicals, etc. Transcriptome analy...

Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma ...