Integration of Pharmaceutical Discovery and Development
Borchardt, Ronald T. / Smith, Philip L. / Sawyer, Tomi K. / Freidinger, Roger M.
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug ...
