Energy Dysregulation in Huntington¿s Disease
Ju, Tz-Chuen
Adenosine monophosphate-activated protein kinase (AMPK) is a major energy sensor that maintains cellular energy homeostasis. Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of CAG repeats in the huntingtin (Htt) gene. Herein, we report that activation of the a1 isoform of AMPK (AMPK-a1) occurred in striatal neurons of humans and mice with HD. Overactivation of AMPK in the striatum caused brain atrophy, facilit...