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In dieser sechsten Auflage von Jack Jie Lis bahnbrechendem Werk "Namensreaktionen" hat der Autor jeweils drei oder mehr Anwendungen in der Synthese zu den Namensreaktionen hinzugefügt, um den jüngsten Fortschritten in der organischen Chemie Rechnung zu tragen. Wie in den vorherigen Ausgaben wird jede Reaktion durch ihren detaillierten Schritt-für-Schritt-Mechanismus beschrieben und mit den ursprünglichen und neuesten Referenzen, insbesondere a...

In his latest book, science writer and medicinal chemist Jie Jack Li guides readers through the history of viruses, vaccines, and antiviral drugs. Li chronicles the discovery and treatment of HIV/AIDS, hepatitis, influenza, and coronaviruses. Throughout, Li focuses on how viruses have shaped human history and on the individuals who developed treatments.

In this sixth edition of Jack Jie Li's seminal "Name Reactions", the author has added three or more synthetic applications of name reactions to reflect the recent advances in organic chemistry. As in previous editions, each reaction is delineated by its detailed step-by-step, electron-pushing mechanism and supplemented with the original and the latest references, especially from review articles. This book is not only an indispensable resource ...

The latest entry in the widely read Drug Synthesis series In Current Drug Synthesis, accomplished medicinal chemist and researcher Dr. Jie Jack Li and 27 expert coauthors deliver an authoritative and comprehensive discussion of the medicinal chemistry of current drugs, as well as the cutting-edge science involved in their synthesis. The book demystifies the process of modern drug discovery for both industry practitioners and students, while c...

This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated with them.

In this sixth edition of Jack Jie Li's seminal "Name Reactions", the author has added three or more synthetic applications of name reactions to reflect the recent advances in organic chemistry. As in previous editions, each reaction is delineated by its detailed step-by-step, electron-pushing mechanism and supplemented with the original and the latest references, especially from review articles. This book is not only an indispensable resource ...

Drug Discovery with Privileged Building Blocks traces back PharmaBlock¿s founding philosophy of designing privileged building blocks. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists and veteran medicinal chemists find it useful as well.

Drug Discovery with Privileged Building Blocks traces back PharmaBlock's founding philosophy of designing privileged building blocks. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists and veteran medicinal chemists find it useful as well.

Over 25 million people in the U.S. alone have benefited from statins--such drugs as Lipitor, Zocor, Crestor, Pravachol, and other cholesterol-lowering medicines--in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells for the first time the fascinating story of...

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could h...

This book offers a good starting point for new medicinal chemists to jump start a career and a one-stop depository of key drug discovery disciplines for veterans. It discusses different kinds of drug targets and how to select and validate them, drug design, pharmacokinetic properties, and bioisoteres"--

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The third edition contains major improvements over the previous edition. In addition to updated references, each reaction is now supplemented with two to three representative examples in synthesis to showcase its synthetic utility. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Furthemore, the subject index is significantly expanded. Different from other books on name reactions in o...

This set presents the authoritative and acclaimed Drug Synthesis books edited by Jie Jack Li and Douglas Johnson: Contemporary Drug Synthesis, The Art of Drug Synthesis, Modern Drug Synthesis, and Innovative Drug Synthesis.

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in...

This book continues in this well-established series of works by presenting a comprehensive treatise on name reactions in homologation reactions. Each section includes a description of the reaction, the historical perspective, a mechanism for the reaction, variations and improvements on the reaction, synthetic utilities of the reaction, experimental details, and references to the current primary literature.

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could h...

Organic chemistry is the science of carbon-containing compounds. There are four major types of reactive intermediates in organic chemistry: carbocations, carboanions, radicals and carbenes. Therefore, carbocation chemistry is not only fundamental to the advancement of organic chemistry, it also has found widespread applications in organic synthesis. It is not an exaggeration to say that carbocation chemistry is part of the foundation of organi...

A survey of important transformations that are representative of the whole range of functional groups This comprehensive reference delves into the details of name reactions that are important to researchers. It presents an up-to-date account of forty-seven major classes of functional group transformations and also serves to interconnect them. The book includes reviews from leading scientists in their specialty areas--all organized uniformly, ...

Examines the cases of several historic and high-profile drugs in order to discuss the future of the pharmaceutical industry.