3 Ergebnisse.

Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the no...

Die Pathogenese der Arteriosklerose ist immer noch weitgehend ungeklärt. In jüngster Zeit zeichnet sich jedoch ein wesentlicher Fortschritt im Verständnis der zugrundeliegenden kausalen Ereignisse ab. Das Entstehen arteriosklerotischer Läsionen beruht mit hoher Wahrscheinlichkeit auf einer Fehlsteuerung der interzellulären Kommunikation, die zum Verlust der Gefäßwandhomöostase führt. In einem komplexen Wechselspiel sind hieran hauptsächlich Wa...

This exhaustive work shows that new therapies using anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer, as tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identif...