Gamma-Glutamyl Transpeptidases
Merlino, Antonello / Castellano, Immacolata
Gamma-Glutamyl Transpeptidases (¿-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the ¿-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released ¿-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). ¿-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it ...