Amide Bond Activation: Concepts and Reactions
Murphy, Caleb Amides refer to functional groups wherein a carbonyl carbon atom is connected by a single bond to a nitrogen atom, and either a hydrogen or a carbon atom. An amide bond refers to a type of peptide bond. The condensation of an amine and a carboxylic acid is the most common process for the creation of this type of bond. The high stability of amide bonds is due to their tendency to create a resonating structure which gives a double bond character...