2 Ergebnisse.

This work is a novel systems biology approach to decipher the identity of specific genes and gene products involved in the advancement of colon cancer from tumorigenesis through to metastasis. Stage-based meta-analysis of tumor genome-sequencing data in public domain was conducted and multiple approaches employed for mining novel genes driving the initiation, progression and metastasis of colon cancer. The consensus stage-specific driver genes...

Potassium (K+) channels are tetrameric membrane proteins that play a critical role in diverse life-sustaining processes, e.g., the action potential. Their clinical significance is underscored by the observation that they are likely the founding members of the voltage-gated ion channel superfamily that includes sodium and calcium channels. The research aimed to address the gaps in our current understanding of K+ channel biology. The themes were...