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Chapter 1 uses SILAC and TMT quantitative MS methods to identify novel target proteins modulated in the erlotinib (EGFR TKI) resistant lung cancer cells. The use of multiplex quantitative proteomic strategies, such as SILAC and TMT protein labeling are powerful methods for identifying a large number of novel biomarkers. Chapter 2 describes a MALDI-TOF/TOF based proteomic approach to profile HAPE-related proteomic changes in plasma. 25 differen...

Chapter 1 presents a comprehensive review of placental chorioangioma, the most common type of non-trophoblastic placental tumor with no risk of metastasis. They are usually small, single and asymptomatic. Chapter 2 discusses the role of Lipoic acid (LA) as antioxidants in lowering the incidence of some pathologies of cardiovascular diseases as well as for anti-aging. LA is a natural antioxidant which is believed to have a beneficial effect on ...

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Coronary artery disease, also called coronary heart disease, or simply, heart disease, is the No. 1 killer in America, affecting more than 13 million Americans according to recent reports. Coronary artery disease is usually a result of plaque buildup in coronary arteries, a condition called atherosclerosis, that leads to blockages. The arteries, which start out smooth and elastic, become narrow and rigid, restricting blood flow to the heart. T...

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