Tyrosine Kinases as Druggable Targets in Cancer
Ren, Huan![Tyrosine Kinases as Druggable Targets in Cancer](https://support.digitalhusky.com/media/annotations/sorted/347/34721277/CHSBZCOP0334721277.jpg)
Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management. In this book, we examine a few aspects of PTKs and cancer, considering ef...