Regulation of the Krüppel-like Factor 6 Tumor Suppressor
Yea, Steven
KLF6 is a ubiquitously expressed Krüppel-like
transcription factor whose role in vitro and in vivo
role has not been fully identified. Like other
members of the Krüppel-like family, KLF6 contains a
conserved C-terminal three zinc finger DNA-binding
domain (C2H2 motifs) and a unique N-terminal
transactivation domain. KLF6 directly binds DNA at GC
box promoter elements. Transcriptional targets of
KLF6 include collagen 1, transforming growth fact...