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Input/Output in Parallel and Distributed Computer Systems has attracted increasing attention over the last few years, as it has become apparent that input/output performance, rather than CPU performance, may be the key limiting factor in the performance of future systems. This I/O bottleneck is caused by the increasing speed mismatch between processing units and storage devices, the use of multiple processors operating simultaneously in parall...

In the era of personalized medicine, cancer treatment has become a model for the use of targeted therapeutics. Leaving behind the "one size fits all" approach to cancer care, this book provides the practicing oncologist with an overview of the advances in treatment and an understanding of the implementation of new therapeutic agents. Targeted Cancer Therapy is divided into twenty chapters covering specific hematologic malignancies and solid tu...

Arturo Carsetti According to molecular Biology, true invariance (life) can exist only within the framework of ongoing autonomous morphogenesis and vice versa. With respect to this secret dialectics, life and cognition appear as indissolubly interlinked. In this sense, for instance, the inner articulation of conceptual spaces appears to be linked to an inner functional development based on a continuous activity of selection and "anchorage" real...

National Institute of Allergy and Infectious Diseases, NIH: Volume III: Intramural Research contains a broad overview of the research activity of the NIAID intramural scientists working in the Division of Intramural Research (DIR) and the Vaccine Research Center (VRC), both in the Bethesda campus, and the Rocky Mountains Research Laboratories. Each of these laboratories employs scientists internationally recognized as leaders in their fields o...

The thoroughly updated and revised third edition of Management of Prostate Cancer provides concise and authoritative guidance to today's best therapeutic regimens for the diagnosis and treatment of prostate cancer.  Highlighting the latest major advances in the field, the book includes chapters on the most controversial areas of prostate cancer – screening, chemoprevention, and active surveillance, updated chapters on genetic risk and progress...

In The Best Guide to Allergy, medical experts answer all your personal concerns and questions about allergy and asthma in easily understood language. Drawing on their extensive experience in treating both children and adults, as well as on the latest research findings, they offer up-to-date, explanations of the causes, care, treatment, remedies, and prevention of these uncomfortable, often debilitating, and sometimes even life-threatening ailm...

Formation of transmembrane pores is a very effective way of killing cells. It is thus not surprising that many bacterial and eukaryotic toxic agents are pore-forming proteins. Pore formation in a target membrane is a complex process composed of several steps, proteins need to attach to the lipid membrane, possibly aggregate in the plane of the membrane and finally form a pore by inserting part of the polypeptide chain across the lipid bilayer....

This comprehensive, yet practical, text is a ready collection of the most up-to-date information on primary CNS tumors. Authored by a carefully selected group of the world’s leading clinicians and scientists, the book is divided into three sections. The opening chapters cover general principles, including epidemiology, pathogenesis, tumor stem cells, supportive care, complications of therapy, and quality of life. The remaining two sections are...

Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the...

Gene therapy offers many conceptual advantages to treat muscle diseases, especially various forms of muscular dystrophies, however, it faces a number of unique challenges, including the need to deliver a therapeutic vector to all muscles throughout the body. In Muscle Gene Therapy: Methods and Protocols, expert researchers in the field present a collection of techniques aimed at bridging the translational gap in muscle gene therapy between the...

The neoplasms found in the female genital tract are numerous and growing more complex. Cytology and Surgical Pathology of Gynecologic Neoplasms has been written to provide a practical reference for practicing pathologists and cytopathologists in a quick and concise fashion. The primary focus of this book is on gynecological tumors, specifically common ones and their benign mimics. Emphasis is placed on morphologic recognition, resolving commo...

This monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers. It deals with the metabolic activation of common classes of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic aromatic hydrocarbons) and their detoxica...

Driven by methodological success in identifying reliable lineage markers, regulatory T cells have quickly been recognized as the most numerous subset of immune regulators in the body with critical functions in a wide array of immune responses. In Regulatory T Cells: Methods and Protocols, experts in the field to offer a collection of current techniques to advance the study of regulatory T cells, including the use of the IL-2 receptor alpha cha...

The human foot is a complex body part composed of fifty-two bones, which is twenty-five percent of all the bones in the body. Nonetheless, the foot is often viewed by the public and doctors as a “minor” body part. Similarly, the importance of pedal evidence in crime investigation has also long been undervalued, but as footwear evidence has become more commonly used in forensic situations, so has pedal evidence, which is why this seminal work i...

A great deal of effort is being invested in understanding the molecular mechanisms through which plants interact with pathogenic microbes.  In  Plant Immunity: Methods and Protocols, expert researchers in the field describe emerging technologies that can be applied to the most significant outstanding questions faced by scientists studying immunity in plants. The technologies in this detailed volume include methods for examining protein localiz...

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Nutrients, Dietary Supplements, and Nutriceuticals: Cost Analysis Versus Clinical Benefits provides the most current, concise, scientific appraisal and economic analysis (costs vs. benefit) of nutritional supplements and bioactive components (nutriceuticals) of foods in improving the quality of life. It fills a much-needed gap to have a single volume provide a synopsis of cost analysis of dietary supplements and nutritional products as well as...

When Dr. David Cundiff called me with a proposal to help research and write The Right Medicine I was intrigued but skep­ tical. His ideas for reform of the US health care system were visionary, radical, and highly original-but would they work? As a Wall Street analyst and long-time student of the health care system, I had my doubts. had read David's book on hospice care, Euthanasia Is Not the I Answer, and was impressed. And I had recently wit...

The Project on Reproductive Laws for the 1990s began in 1985 with the realization that reports of scientific developments and new technologies were stimulating debates and discussions among bioethicists and policymakers, and that women had little part in those discussions either as participants or as a group with interests to be considered. With the help of a planning grant from the Rutgers University Institute for Research on Women, the Women...

The number of children with allergies is astounding-nearly one child in six is said to suffer from some sort of allergy. The problems of these allergic children can be as mild as occasional attacks of hay fever or as severe as disfiguring eczema and life-threatening bronchial asthma. In addition to the obvious health problems associated with having allergies, affected children may experience recurring colds, painful ear infections, and other a...