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GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. This book brings together many of the world’s leading investigators to discuss current and anticipated developments in the areas of geriatric sleep medicine and provides a comprehensive examination of current principles and practice in this fiel...

Tamari lattices originated from weakenings or reinterpretations of the familar associativity law. This was the subject of Dov Tamari's thesis at the Sorbonne in Paris in 1951 and the central theme of his subsequent mathematical work. Tamari lattices can be realized in terms of polytopes called associahedra, which in fact also appeared first in Tamari's thesis. By now these beautiful structures have made their appearance in many different areas...

The book presents the modern state of the art in the mathematical theory of compressible Navier-Stokes equations, with particular emphasis on applications to aerodynamics. The topics covered include: modeling of compressible viscous flows, modern mathematical theory of nonhomogeneous boundary value problems for viscous gas dynamics equations, applications to optimal shape design in aerodynamics, kinetic theory for equations with oscillating da...

This volume is dedicated to Professor Stefan Samko on the occasion of his seventieth birthday. The contributions display the range of his scientific interests in harmonic analysis and operator theory. Particular attention is paid to fractional integrals and derivatives, singular, hypersingular and potential operators in variable exponent spaces, pseudodifferential operators in various modern function and distribution spaces, as well as related...

This new volume in the Poincaré Seminar Series, describing recent developments at the interface between physics and biology, is directed towards a broad audience of physicists, biologists, and mathematicians. Both the theoretical and experimental aspects are covered, and particular care is devoted to the pedagogical nature of the presentations. The first survey article, by Jean-Francois Joanny and Jacques Prost, describes the theoretical advan...

This practical guidebook describes the basic concepts, the mathematical developments, and the engineering methodologies for exploiting possibility theory for the computer-based design of an information fusion system where the goal is decision support for industries in smart ICT (information and communications technologies). This exploitation of possibility theory improves upon probability theory, complements Dempster-Shafer theory, and fills a...

This volume details methods used to track cells in the body and will serve as a reference for preclinical and clinical researchers in the fields of medicine and biomedical science. Chapters guide readers through protocols on bioluminescence imaging, fluorescence imaging, magnetic resonance imaging (MRI), ultrasound, computed tomography, and positron emission spectroscopy. Written in the highly successful Methods in Molecular Biology series for...

This book provides comprehensive coverage of the latest research into integrated circuits’ ageing, explaining the causes of this phenomenon, describing its effects on electronic systems, and providing mitigation techniques to build ageing-resilient circuits.  Describes in detail the physical mechanisms of CMOS ageing, Provides an in-depth discussion on the impact of ageing on the performance and reliability of integrated circuits, Presents st...

This book presents a framework for the control of networked systems utilizing submodular optimization techniques. The main focus is on selecting input nodes for the control of networked systems, an inherently discrete optimization problem with applications in power system stability, social influence dynamics, and the control of vehicle formations. The first part of the book is devoted to background information on submodular functions, matroids...

This book discusses the design principles of physically unclonable functions (PUFs) and how these can be employed in hardware-based security applications, in particular, the book:Provides readers with a comprehensive overview of security threats on embedded systems and existing countermeasures, Includes an intensive tutorial on how to design and evaluate physically unclonable functions, supported by circuit diagrams and exemplar hardware imple...

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This volume contains 17 mathematical works by Johann Bernoulli, written between 1680 - when he was only 13 years old and studied mathematics with his brother Jacob - and 1732, when he was 65 years old. Five of the works are handwritten manuscripts, and another three belong to the Anekdota, which he published in the fourth volume of his Opera Omnia. The book features also seven works by other authors: John Craig, Jacob Hermann, Gottfried Wi...

In der Bundesrepublik Deutschland überwachen die Behörden der Länder die Einhaltung der Vorschriften, die für das Inverkehrbringen und die Anwendung von Pflanzenschutzmitteln gelten. Das Pflanzenschutz-Kontrollprogramm ist ein bundesweit harmonisiertes Programm zur Überwachung pflanzenschutzrechtlicher Vorschriften. Die Durchführung und Berichterstattung der Kontrollen erfolgten nach gemeinsamen Standards der Länder auf Grundlage eines abgesti...

Die Anwendung von antibakteriell wirksamen Substanzen in der Veterinärmedizin erfolgt zum einen aus Gründen des Verbraucherschutzes, zum anderen zur Erhaltung der Tiergesundheit. Gleichzeitig führt jeder Einsatz von Antibiotika zur Selektion von bereits bestehenden Resistenzen, auch wird das Entstehen neuer Resistenzmechanismen begünstigt.Aus diesen Gründen müssen nachhaltig wirksame Managementmaßnahmen ergriffen werden, um den Eintrag von res...

Das Buch bietet eine Einführung in die Topologie, Differentialtopologie und Differentialgeometrie. Nach einer Einführung in grundlegende Begriffe und Resultate aus der mengentheoretischen Topologie wird der Jordansche Kurvensatz für Polygonzüge bewiesen und damit eine erste Idee davon vermittelt, welcher Art tiefere topologische Probleme sind. Im zweiten Kapitel werden Mannigfaltigkeiten und Liesche Gruppen eingeführt und an einer Reihe von Be...

This book provides an introduction to topology, differential topology, and differential geometry. It is based on manuscripts refined through use in a variety of lecture courses. The first chapter covers elementary results and concepts from point-set topology. An exception is the Jordan Curve Theorem, which is proved for polygonal paths and is intended to give students a first glimpse into the nature of deeper topological problems.The second ch...

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In modern ecotoxicology, fish have become the major vertebrate model, and a tremendous body of information has been accumulated. This volume attempts to summarize our present knowledge in several fields of primary ecotoxicological interest ranging from the use of (ultra)structural modifications of selected cell systems as sources of biomarkers for environmental impact over novel approaches to monitoring the impact of xenobiotics with fish in ...