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Distributed applications are difficult to write as programmers need to adhere to specific distributed systems programming conventions and frameworks, which makes distributed systems development complex and error prone and ties the resultant application to the distributed system because the application's code is tangled with the crosscutting concern distribution. This book introduces the concept of a domain-specific aspect language called a Di...

The theory of elliptic partial differential equations has undergone an important development over the last two centuries. Together with electrostatics, heat and mass diffusion, hydrodynamics and many other applications, it has become one of the most richly enhanced fields of mathematics. This monograph undertakes a systematic presentation of the theory of general elliptic operators. The author discusses a priori estimates, normal solvability, ...

Der Band ist an der Schnittstelle zwischen linearer Algebra und rechnerischer Geometrie angesiedelt. Einerseits werden die klassischen Geometrien mit Mitteln der linearen Algebra behandelt, andererseits grundlegende Strukturen der rechnerischen Geometrie und algorithmische Methoden diskutiert. Der Schwerpunkt liegt auf den geometrischen Eigenschaften, wobei auch relevante algorithmische Konzepte vorgestellt werden. Geeignet für die Studienrich...

Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterati...

on constant tectonic loading are as good as or better Other geophysical measurements may also bere- than time-varying earthquake likelihood models ted to earthquake occurrence, and such relationships determinedfrom the evolving stress ?eld. are examinedin some of the papers herein. ITABA et al. One approach to understanding earthquakes isto compare groundwater and crustal deformation to create synthetic earthquake catalogues using certain seis...

A collection of papers from Paul Hertz to Dov Gabbay - through Tarski, Gödel, Kripke - giving a general perspective about logical systems. These papers discuss questions such as the relativity and nature of logic, present tools such as consequence operators and combinations of logics, prove theorems such as translations between logics, investigate the domain of validity and application of fundamental results such as compactness and completenes...

Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities t...

Anwendungsnah und anschaulich: Die Autoren greifen den modernen Ansatz der Stochastik auf, der Wahrscheinlichkeiten immer im Zusammenhang mit Zufallsvariablen behandelt. Das Konzept der Zufallsgrößen prägt die Ausarbeitung der Autoren. Im vorliegenden Buch erläutern sie Zufallsvariablen, zufällige Pfade oder die Anfänge der Markovketten. Anhand ausführlicher Beispiele, Übungsaufgaben und Ausblicke setzen sie sämtliche Themen in einen größeren ...

Der Band stellt mathematikdidaktisches Basiswissen bereit, das für den Unterricht in der Sekundarstufe relevant ist. Im Fokus steht dabei ein schülerorientierter und kognitiv aktivierender Mathematikunterricht, der inhaltlich und konzeptionell auf den aktuell gültigen Bildungsstandards aufbaut. Einerseits werden theoretische Ideen und empirische Evidenz rund um das Lehren und Lernen beschrieben, andererseits steht die Auseinandersetzung mit de...

Das Buch gibt eine Einführung in zentrale Konzepte und Methoden der Nichtlinearen Optimierung. Es ist aus Vorlesungen der Autoren an der TU München, der TU Darmstadt und der Universität Hamburg entstanden. Der Inhalt des Buches wurde insbesondere auf mathematische Bachelorstudiengänge zugeschnitten und hat sich als Basis entsprechender Vorlesungen sowie für eine anschließende Vertiefung im Bereich der Optimierung bewährt. Der Umfang entspricht...

This special issue of Pure and Applied Geophysics is one of two volumes containing an augmented collection of papers originating from the Evison Symposium on Seismogenesis and Earthquake Forecasting held in Wellington, New Zealand, in February 2008. The volumes honor Frank Evison's interest in earthquake generation and forecasting. A biography of Frank Evison and a list of his publications is included, as well as review papers and new research...

The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses...

The purpose of the volume is to bring forward recent trends of research in hypercomplex analysis. The list of contributors includes first rate mathematicians and young researchers working on several different aspects in quaternionic and Clifford analysis. Besides original research papers, there are papers providing the state-of-the-art of a specific topic, sometimes containing interdisciplinary fields. The intended audience includes researcher...

Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several ot...

Automorphic forms on the upper half plane have been studied for a long time. Most attention has gone to the holomorphic automorphic forms, with numerous applications to number theory. Maass, [34], started a systematic study of real analytic automorphic forms. He extended Hecke's relation between automorphic forms and Dirichlet series to real analytic automorphic forms. The names Selberg and Roelcke are connected to the spectral theory of real ...

Stress re-distribution as a result of exploitation of mineral, hydrocarbon, geothermal, and water resources cannot be eliminated. The effort must be directed to a better understanding of the underlying processes for the management of the hazard and risk associated with these operations. The study of induced seismicity has continually evolved over the past couple of decades, as underlined by both the number and complexity of applied studies req...

Affine flag manifolds are infinite dimensional versions of familiar objects such as Graßmann varieties. The book features lecture notes, survey articles, and research notes - based on workshops held in Berlin, Essen, and Madrid - explaining the significance of these and related objects (such as double affine Hecke algebras and affine Springer fibers) in representation theory (e.g., the theory of symmetric polynomials), arithmetic geometry (e.g...

Leon Battista Alberti (1404¬–1472) was a highly prolific polymath of the fifteenth century. Although his contributions to architecture and the visual arts are well known and available in good English editions, as are many of his literary and social writings, his mathematical works are not well represented. This present volume was planned to fill that gap, with entirely new English translations and critical commentaries making the works easily ...

Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the treatment of HER-2-positive advanced metastatic breast cancer, a new era has dawned in the the...

Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechani...