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This book provides an introduction to human cytogenetics. It is also suitable for use as a text in a general cytogenetics course, since the basic features of chromosome structure and behavior are shared by all eukary­ otes. Because my own background includes plant and animal cytogenet­ ics, many of the examples are taken from organisms other than the human. Since the book is written from a cytogeneticist's point of view, human syndromes are de...

Developed by the Blood and Marrow Transplant team at Oregon Health & Science University Knight Cancer Institute, this pocket guide provides medical management guidelines for hematopoietic stem cell transplant patients from the moment of their initial consultation throughout the transplant process. - It includes indications for transplant, essential details for patient/donor evaluation, - recommendations for addressing complications during a...

This fully updated volume explores recently improved avenues to study urothelial carcinomas. Beginning with several novel chapters on molecular characterization and urothelial carcinogenesis, the book continues with sections on cellular and animal models, biomarkers, and approaches for targeted therapy. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the...

This volume focuses on games to manage and facilitate rehabilitation. It emphasizes user practice, attitudes, and experience, and their changing place within developing rehabilitation frameworks. It looks at how users have adopted, integrated, and innovated with games to facilitate rehabilitation. Topics include game technology, game design and accessibility, web-based technologies vs pervasive and mobile technologies, social and collaborative...

This second edition details new and updated chapters on key methodologies and breakthroughs in the mass spectrometry imaging (MSI) field. Chapters guide readers through nano-Desorption Electrospray Ionisation (nDESI), Matrix Assisted Laser Desorption Ionisation-2 (MALDI-2), Laser Ablation - Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) , Imaging Mass Cytometry (IMC) with a variety of diverse samples including eye tissue, crop analys...

This volume looks at the latest methods used to study imaging techniques, metabolic tracing, and deep muscle phenotyping. The chapters in this book cover topics such as imaging skeletal muscle mass using MRI, dual-energy x-ray absorptiometry, CT, and ultrasound, measures of neuromuscular function such as power/strength/force, microscopy and immunohistochemistry, and ex vivo fibre function and isolation. In the Neuromethods series style, chapte...

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This book explores total information awareness empowered by social media. At the FBI Citizens Academy in February 2021, I asked the FBI about the January 6 Capitol riot organized on social media that led to the unprecedented ban of a sitting U.S. President by all major social networks. In March 2021, Facebook CEO Mark Zuckerberg, Google CEO Sundar Pichai, and Twitter CEO Jack Dorsey appeared before Congress to face criticism about their handli...

This detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities. Divided into three sections, the collection explores greener approaches to chemical transformations that are both prevalent and have been highlighted as challenging within the pharmaceutical industry, overa...

This book provides an account of multivariate reduced-rank regression, a tool of multivariate analysis that enjoys a broad array of applications. In addition to a historical review of the topic, its connection to other widely used statistical methods, such as multivariate analysis of variance (MANOVA), discriminant analysis, principal components, canonical correlation analysis, and errors-in-variables models, is also discussed. This new edit...

This volume in the Encyclopedia of Complexity and Systems Science, Second Edition, is devoted to the fundamentals of Perturbation Theory (PT) as well as key applications areas such as Classical and Quantum Mechanics, Celestial Mechanics, and Molecular Dynamics. Less traditional fields of application, such as Biological Evolution, are also discussed. Leading scientists in each area of the field provide a comprehensive picture of the landscape a...

This newly updated volume of the Encyclopedia of Complexity and Systems Science (ECSS) presents several mathematical models that describe this physical phenomenon, including the famous non-linear equation Korteweg-de-Vries (KdV) that represents the canonical form of solitons. Also, there exists a class of nonlinear partial differential equations that led to solitons, e.g., Kadomtsev-Petviashvili (KP), Klein-Gordon (KG), Sine-Gordon (SG), Non-L...

Tracing the life of a giant in inorganic chemistry and key trends in his science, Boranes and Beyond follows Hawthorne from his mid-American origins to the halls of Harvard and UCLA and back again. It naturally details the accomplishments in his lab. This book is a fascinating mixture of science and autobiography. Prof. Hawthorne won the Priestley Medal, the highest award of the American Chemical Society, for his pioneering work in elucidating...

This collection explores the latest advances in riboregulators, such as RNA-only systems and ribonucleoprotein systems, and provides detailed techniques to study, evolve, and design them. Beginning with a set of chapters focused on the design and application of small RNA (sRNA) regulator systems, the book continues with sections on techniques to create switchable riboregulator systems known as riboswitches, technologies that leverage RNA-guide...

This book covers two major classes of mixed effects models, linear mixed models and generalized linear mixed models. It presents an up-to-date account of theory and methods in analysis of these models as well as their applications in various fields. The book offers a systematic approach to inference about non-Gaussian linear mixed models. Furthermore, it includes recently developed methods, such as mixed model diagnostics, mixed model selectio...

This edited volume records the critical historical developments in thermal physiology and makes them accessible to new and senior thermal biologists and scientists in related fields. Readers will discover how the discipline developed all over the world. Contributions from 14 different countries recollect all prominent discoveries, starting in the 18th century. Like other volumes of the Perspectives in Physiology series, this book reveals the p...

This volume provides a wide range of aspects related to mycoremediation, which can be applied for both basic and advanced multidisciplinary research. Chapters guide readers through screening of fungi, Polyaromatic Hydrocarbons (PAHs), textile dyes, pesticides, bioreactors, molecular methods, redictive Mycology and Proteomics approaches to select fungi, elucidating biological mechanisms, and fungal laccase enzyme-based biosensors for the detect...

This volume provides inflammasome instructions and tips to study different aspects of inflammasome biology. Chapters guide readers through how to assess canonical and non-canonical inflammasome activation, in vitro immune and non-immune cells, whole blood, biochemical assays to evaluate ASC oligomerization, gasdermin D cleavage, and mapping phosphorylated residues of NLRP3. Written in the format of the highly successful Methods in Molecular Bi...

This detailed volume explores techniques for researching brown adipose tissue (BAT) and the fascinating biology and therapeutic potential of thermogenic adipocytes. The content reflects the advancing technologies in genetics, imaging, and 'omics strategies that are allowing researchers to probe BAT biology at unprecedented depths and detail, yet it also presents classic physiology principles, which remain the core tenets of BAT biology. Writte...