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This book introduces mathematical modeling methods for calculating the profiles of plasma levels obtained with controlled release dosage forms and provides examples and case studies to illustrate the techniques employed. The mathematical models developed by the author are particularly powerful because they account for such major parameters as the kinetics of drug release controlled by diffusion or by erosion, and the kinetics of absorption int...

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Topics in this broad study of the Celtic religion include the gods of Gaul, the Irish mythological cycle, gods and men, nature, plant and animal worship, cosmogony, sacrifice, festivals, the Druids, magic, and rebirth.

Grid Database Design investigates the origin, background, and components of this new computing model. This book presents new concepts and analyzes pre-existing ideas in the context of Grid, educating organizations as to how Grid can increase their computing power and strengthen their operations. Divided into three sections, the volume begins by laying the groundwork in the field, defining the concepts that led to the model's emergence. The sec...

Strategic Software Engineering: An Interdisciplinary Approach addresses technical and scientific aspects of software development in a way that is accessible to a wide audience. It provides a review of software development models and processes, followed with an assessment of how process models evolved over time and what directions should be taken to improve them. The authors then focus on the relation between problem-solving techniques and stra...

Offers advice for project and application managers looking to minimize the number of crises they have to deal with and for IT practitioners seeking the practical solutions that lead to career advancement. This book focuses on software development and maintenance, highlighting the most frequently encountered problems that arise from poor processes.

Until now, there were few textbooks that focused on the dynamic subject of speculative execution, a topic that is crucial to the development of high performance computer architectures. Speculative Execution in High Performance Computer Architectures describes many recent advances in speculative execution techniques. It covers cutting-edge research projects, as well as numerous commercial implementations that demonstrate the value of this laten...

A detailed analysis and explanation of granite landforms, focused exclusively on granitic terrains and their structures, forms and surfaces.

Presenting an examination of aspects of twentieth century history this book explores how the events of the twentieth century still cast a shadow over relations between Germany, Poland and the Czech Republic.

The pharmaceutical industry suffers from an innovation deficit, with clinical attrition and safety-related market-withdrawal rates at the same level as twenty years ago. This book scrutinizes this problem in detail, contrasting the promise of technology and industrialization with the apparent inability of industry to fully realize the tools that are available. The text begins by introducing the evolution of modern drug discovery, tracing it fr...

The NHS is an institution of great importance to everybody in the UK - not only doctors, nurses and other health professionals, but also to patients, carers and their families. However, problems within the NHS are regularly reported in the media and we are all anxious about waiting lists, about whether potential illnesses will be identified treated in time, about bleeding to death on trollies in corridors or being struck down by antibiotic-res...

Synthesizing current information about sensory-motor plasticity, this book provides an up-to-date description of the dynamic processes that occur in somatic sensory-motor cortical circuits or somatic sensory pathways to the cortex due to experience, learning, or damage to the nervous system. The presentation emphasizes changes in the cortex that are linked to changes in movement or behavior and demonstrates the potential for direct brain-based...

These papers describe and explain architectural paint research and its role in understanding and managing historic buildings. The papers are derived from a national seminar held in London by English Heritage during 2000.

Stuart Hampshire, one of the most eminent British philosophers of the twentieth century, will be perhaps best remembered for his work on the seventeenth-century philosopher Spinoza, all of which is gathered now in this volume. Among the great thinkers of modern times, only Spinoza created a complete system of philosophy that rivals Plato's, with crucial contributions to every major philosophical topic. Hampshire's classic 1951 book Spinoza rem...

How did Andrei Sakharov, a theoretical physicist and the acknowledged father of the Soviet hydrogen bomb, become a human rights activist and the first Russian to win the Nobel Peace Prize? In his later years, Sakharov noted in his diary that he was "simply a man with an unusual fate." Tounderstand this deceptively straightforward statement by an extraordinary man, The World of Andrei Sakharov, the first authoritative study of Andrei Sakharov a...

This Dictionary is an abridged edition of The Oxford English-Urdu Dictionary, which was translated and compiled by Shanul Haq Haqqee, the renowned scholar, lexicographer, and an authority on the Urdu language. It contains more than 40, 000 entries and about 50, 000 definitions. This dictionary includes features such as tips on good grammar as well as punctuation.

Peter Carruthers's essays on consciousness and related issues have had a substantial impact on the field, and many of his best are now collected here in revised form. Together they develop, defend, and explore the implications of Carruthers's distinctive theory of experiential consciousness, they discuss the differences between conscious experiencing and conscious thinking, and, controversially, they consider what would follow, either for mora...

Volume XX/1 of History of Universities contains the customary mix of learned articles, book reviews, conference reports, and bibliographical information, which makes this publication such an indispensable tool for the historian of higher education. Its contributions range widely geographically, chronologically, and in subject-matter. The volume is, as always, a lively combination of original research and invaluable reference material.

In this genuinely productive interdisciplinary dialogue, engineering scientists, archaeologists and historians discuss how recent exciting developments in imaging, image analysis, and image display/diffusion can be applied to three-dimensional objects of material culture from the classical world, ranging from inscribed writing tablets to buildings and urban sites. The fifteen papers explore the ways in which the scientific contributors and the...

This book investigates the way grammar deals with the representation of aspectual (aktionsart) concepts, focussing on issues of the lexicon-syntax interface. The authors' innovative analyses of this interface significantly advance our understanding of the role that syntax plays in determining verbal meaning, aspectual interpretation, and thematic information. Various theories are developed in this collection, including those that take as their...