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In 1906, Hermann Leuchs, a student of Emil Fischer, discovered the class of N-Carboxy-aminoacid-anhydrides, also known as Leuch's anhydrides, or abbreviated NCAs. These compounds are, even 80 years after their discovery, valuable intermediates in organic synthesis due to their reactivity: NCAs polymerize with the elimination of carbondioxide to yield polypeptides, model compounds for proteins. They can be used as starting material for a variet...

The introduction of the operating microscope as a surgical tool revolutionized the treatment of peripheral nerve lesions. A new era thus began in the early 1960s, which led to a substantial improvement in the management of nerve lesions. The results of nerve grafting techniques have demonstrated that, independent of the length of the defect, lesions can be successfully bridged. The free tissue transplants with microvascular anastomosis have al...

Today, the basic mood of researchers and clinical investigators, both at the center and on the periphery of interferon studies, is optimistic regarding the future of interferons as therapeutic substances. Many also feel these polypeptides will prove invaluable probes in unraveling certain fundamental biochemical processes which control the life cycle and developmental pattern of many human cells. In contrast, only a year or two ago, this optim...

It is refreshing to find a book treating alkaloid analysis with all the latest techniques such as inverse-detected two dimensional NMR, GC/MS, and HPLC associated techniques. There have been many developments in the field of alkaloid analysis since the 1950s, not the least of which are the various powerful spectroscopic methods, which dominate this volume. Included also are the various aspects of tobacco alkaloids and analysis in various situa...

The major cause of death in the Western world is some form of vascular disease, and principal among these forms is atherosclerotic heart disease (ASHD). Although much is known about the etiology and treatment of ASHD, there is, as yet, no specific means of prognosis of an impending coronary episode. There are, however, several indications of susceptibility to coronary disease, generally known as risk factors, the foremost of which is hyperlipi...

M. Pliftski Institute of Oceanography, GdaJisk University 46 Pilsudskiego Av. 81-378 Gdynia, Poland 2 The Baltic Sea with 366, 000 km is only 0. 1% of the world's oceans but nevertheless, unique in many ways. The Baltic Sea is the largest area of brackish water in the world. As a formation of nature, it is a sea that in many ways resembles a lake. This makes its flora and fauna interesting and well adapted to the brackish water environment. Th...

Eight carefully written articles on the interactions between the ideas and concepts of particle physics and those of astrophysics make up this book. Two long introductory lectures give a survey of modern concepts in particle physics and in astrophysics and cosmology, stressing features of common interest. The other six contributions deal with the physics of supernova explosions, with black holes, with neutrino oscillations, with the importance...

Das Gabler Lexikon Vertrieb und Handel informiert über alle Bereiche der Vertriebspolitik, z.B. Außenhandel und seine Finanzierung, Beschwerdemanagement, Handelsmanagement, Kaufrecht, Logistik und vieles mehr.

Karl-Heinz von Lackum beschreibt, wie kleine und mittelständische Unternehmen von einer starken Firmen- oder Produktmarke profitieren können, und gibt dem Leser einen anschaulichen Leitfaden an die Hand, mit dem der Markenaufbau Schritt für Schritt gelingt. Ein flott geschriebenes und inspirierendes Buch, das Lust macht auf die eigene Marke.

Das Buch behandelt den Einfluß der Gebäudeplanung auf die Wirtschaftlichkeit von Betrieben: Baukosten, Sicherung der Bedingungen für die vorgesehene Gebäudenutzung, Betriebskosten und Bauunterhaltungskosten, Personal- und Sachkosten. Ausführlich werden die Eigenschaften geplanter Gebäude auf die späteren Personal- und Sachkosten diskutiert.

1m Jahre 1989 veranstalteten wir anHiBlich des lOjahrigen Bestehens der Onkologi­ schen Abteilung an der Thoraxklinik Heidelberg-Rohrbach ein speziell onkologi­ sches Symposium, in dem der jetzige Leistungsstandard vor dem historischen Hin­ tergrund des Krankenhauses dargestellt wurde. Der "runde Geburtstag" des einen Herausgebers im Juni 1991 fUhrte internatio­ nal renommierte Wissenschaftler und Kliniker aus dem In- und Ausland, die der Thor...

En Cuba, existen seis razas de maíz con una alta diversidad morfoagronómica, la cual ha sido ampliamente estudiada, sin embargo, no se conoce la diversidad y características nutricionales, ni se han introducido variedades mejoradas para este fin. El presente trabajo se realizó en una muestra de 106 accesiones, donde se incluyeron accesiones conservadas in situ en fincas de campesinos y conservadas ex situ. Los resultados obtenidos permitieron ...

La escuela de hoy no es un simple espacio de convivencia deseable para nuestros hijos. A pesar que el hombre tiene una naturaleza convivencial, esto no niega que las relaciones pueden deteriorarse a menudo surgiendo el conflicto que es connatural a la dinámica social. Los desacuerdos, las tensiones interpersonales, los enfrentamientos personales e intergrupales pueden adoptar un carácter violento o destructivo que pueden dañar la convivencia. ...

El objetivo principal de nuestro trabajo fue determinar el impacto de la co-expresión de los receptores de factor de crecimiento epidérmico EGFR y Her2 en la supervivencia libre de enfermedad (SLE) y en la supervivencia libre de fracaso pélvico (SLFP) en pacientes con cáncer de cérvix local avanzado (CCLA) tratadas con quimioradioterapia concurrente. La expresión de EGFR y Her2 fue evaluada mediante técnicas inmunohistoquímicas de manera centr...

Discussing ethics applied to finance can become a trivial and selfjustifying task if left to the practical men, or a task with no connection to reality, if performed by philosophers. This book, however, turns out to be an exciting piece of work, useful, provocative, full of ideas and suggestions, as experts in ethics discuss specific issues related to the financial institutions and markets, with the men and women that carry out the daily pract...

It is with great pleasure that I respond to the kind invitation of the BAF project to contribute prefatory remarks to this account of their work, carried out under the auspices of the RACE Programme (Research and Development in Advanced Communications in Europe). The objective of the RACE Programme was to support the intro­ duction of Integrated Broadband Communications in the European Union. An important part of this overall objective was ser...

This book is based on the NATO Advanced Research Workshop on Structures of Com­ munication and Intelligent Help for Hypermedia Courseware, which was held at Espinho, Portugal, April 19-24, 1990. The texts included here should not be regarded as untouched proceedings of this meeting, but as the result of the reflections which took place there and which led the authors to revise their texts in that light. The Espinho ARW was itself to some exten...

Concurrent systems abound in human experience but their fully adequate conceptualization as yet eludes our most able thinkers. The COSY (ConcurrentSystem) notation and theory was developed in the last decade as one of a number of mathematical approaches for conceptualizing and analyzing concurrent and reactive systems. The COSY approach extends theconventional notions of grammar and automaton from formal language and automata theory to...

This chapter provides abrief overview of organoborane reaction types. Reaction mechanisms are discussed, particularly with reference to whether they may or may not allow stereocontrol, but stereocontrolled applications are deferred to later chap­ ters. Reactions that replace boron by atoms other than carbon are discussed first (Section 3. 2), followed by boron substituted carbanions (Section 3. 3) and reactions that have the net effect of repl...

Physics of the Inner Heliosphere gives for the first time a comprehensive and complete summary of our knowledge of the inner solar system. Using data collected over more than 11 years by the HELIOS twin solar probes, one of the most successful ventures in unmanned space exploration, the authors have compiled 10 extensive reviews of the physical processes of the inner heliosphere and their connections to the solar atmosphere. Researchers and ad...