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Neun Schimmel mit Melanomen erhielten eine einmalige intratumorale Injektion mit 250 µg für IL-12 kodierender Plasmid-DNA. Bis vierzehn Tage post injectionem wurden zu 12 Zeitpunkten Proben aus Tumorgewebe und Blut entnommen. Mittels Real-Time PCR wurde die Plasmid-DNA-Menge im venösen Blut und im Tumorgewebe quantifiziert sowie die Expression der IL-12-Plasmid-mRNA und der IFN-¿-mRNA im Tumorgewebe untersucht. Der Hauptanteil der intratumoral...

Quattro amici si incontrano casualmente in una suggestiva località balneare, ma dopo la prima settimana, tormentata da desideri inconfessabili, Simona medita di rientrare a casa anzitempo. La ragazza è legata a Francesca da una sincera e tenera amicizia, ma in cuor suo arde di desiderio per il ragazzo di lei. Una situazione pressoché disperata, inaspettatamente però, sarà proprio l'amica a farle da sponda, in quella ed altre avventure imprevis...

Perinatal depression is described as the depression during pregnancy, around childbirth or within the first year post-partum. This book encompasses significant information regarding the epidemiological, biological, psychological and clinical facets of common mental disorders during pregnancy and in the postnatal period. The topics encompassed in this book include: comprehending the effect of anxiety and depression during pregnancy and in the p...

This book is a research book presented in a way that all the chapters complement each other, to provide the reader with a closer look in the field of combustion. The topics covered are related to advanced studies of applications of combustion in highly advanced technologies, they also discuss control combustion and energy extraction from this technique. It is aimed that this book will be a beginning of a progress that will bring more insights ...

All the selected applications of computed tomography are described in this insightful book. Computed tomography is a crucial imaging method in clinical practice. It was introduced in 1970s and since then, it has advanced and improved to a great extent. For instance, the introduction of helical systems has allowed the development of the "volumetric CT" concept. Even the anthropomorphic, forensic, paleontological and archeological applications o...

This book presents an updated account on the latest discoveries in the field of research and treatment of amyloidosis. Amyloidosis is a rare disorder identified by the accumulation of extracellular amyloid proteins in tissues. Important developments have been made lately, not only offering an insight in to the pathophysiology of the disease but also aiding discovery of novel therapies to fight this deadly disease. Efficient and even curative t...

A photodiode is described as a semiconductor diode which generates a potential difference or changes its electrical resistance when it is exposed to light. This book reflects current development and expansion of photodiodes, inclusive of the primary reviews and the precise applications developed by the writers themselves. The key thought behind this book is to enable authors to deal with a broad variety of background and highlight the progress...

Business and judgment involve a definite amount of risk. Risk might cause loss for a company. This does not denote that businesses cannot take risks. Distancing and risk animosity may result in missed business opportunities, which, in turn will lead to slower development and reduced success of a company. In today's complex and varied environment, it is vital to find the correct balance between risk aversion and risk taking. To do this, it is n...

Meningiomas is a tumor arising from meningeal tissue of the brain. This book caters to neurosurgeons who intend to enhance their knowledge on the contemporary techniques regarding meningiomas operation and management. It presents an account of up-to-date information on management of meningiomas. The content within this text is of excellent quality and presents the latest approaches for dealing with different aspects. The book emphasizes on spe...

The analysis and control mechanism of vibrations are elucidated in this extensive book. Vibration is a phenomenon that we can notice in various systems since its impact can vary vastly from the personal discomfort generated from the unevenness of a road to the downfall of a building or a bridge at the time of earthquake. This book is an abridgement of research works on vibration examination and control. It reflects on new techniques that help ...

This book is prepared by the specialists in the field of microelectromechanical systems (MEMS). It consists of two major sections dedicated to BioMEMS Devices, and MEMS characterization and micromachining. The developments of MEMS and devices have been influential in the demonstration of new devices and techniques, and even in the influx of new fields of research and development such as BioMEMS, actuators, microfluidic devices, RF and optical ...

This book is a concise and sophisticated introduction to bronchial asthma. Asthma remains a severe cause of anxiety for a lot of people worldwide. This book discusses topics related to the diagnosis, prevalence and progression of asthma. It also includes studies of the immunological responses to the advancement and progression of this disease. Furthermore, the book comprises of an analysis of the emerging treatment strategies regarding the man...

This book is a one-stop source of information on current cancer treatments, providing readers with the necessary background to interpret latest information available on evolving alternative treatments. This reflects that an ultimate treatment has not yet been found, and it needs more time and research to develop more effective methods for cancer treatment. This book will serve not just physicians but also patients with an overview on new resea...

A chemical byproduct obtained from petroleum and natural gas is defined as a petrochemical. The petrochemical industry forms a significant part of our pursuit of economic development, generation of employment and basic needs. It is a vast field that covers several commercial chemicals and polymers. This book is formulated to assist the reader, specifically students and researchers of petroleum science and engineering, in comprehending the mech...

This book consists of ideas and information contributed by several academic and research veterans from across the globe. The book presents an analysis of the most important information and educates the readers with quality content elucidating novel directions and rising trends in orthodontics. The topics are organized under three sections namely, orthodontic therapy, demystification of cranio-mandibular dysfunction, and risk evaluation of orth...

The alloys in which aluminium is the predominant metal are referred to as aluminium alloys. Aluminium alloys have grown and improved in various aspects and applications. Due to this transformation, aluminium alloys have been widely utilized in European automotive and space industries. This book collects latest data and graphics provided by experts dealing with this subject. It also discusses the effects of processing parameters on the performa...

Welfare is an essential aspect for the development of a nation. This book presents, for the first time, an extensive, internationally-focused collection of cutting-edge work from leading academics. Its multi-disciplinary approach and relative viewpoint encourages an examination of the most pressing social welfare issues of the day. The book intends to simplify some of the doubts regarding social welfare, and talks about the pros and cons of pr...

This book presents a reliable crystallization of some of the developing biomedical research topics and developments in the field of biotechnology. It puts together promising fundamental research topics on plant and biomedical technologies. It also enables the reader to understand the role of biotechnology in society, answering obvious questions pertaining to biotech procedure and principles in the context of research advances. In an age of mul...

You are about to meet a man by reading over forty years of his writings. In many ways, it is neither an easy introduction nor a comfortable journey. You will not be meeting the man as the person he is-you will be experiencing his process of becoming. The poems begin in the author's early youth, with strong narratives that recount an inherited persona of streetwise toughness. Some of these early poems define, some bruise, some shock. In their ...

You are about to meet a man by reading over forty years of his writings. In many ways, it is neither an easy introduction nor a comfortable journey. You will not be meeting the man as the person he is-you will be experiencing his process of becoming. The poems begin in the author's early youth, with strong narratives that recount an inherited persona of streetwise toughness. Some of these early poems define, some bruise, some shock. In their ...