Written and edited by experts in the field, this collection provides a comprehensive update on the cell signaling that underlies the main cell death programs (apoptosis, pyroptosis, and necroptosis) and how this knowledge is driving the development of therapeutic drugs to treat some human diseases. Contributors describe in detail the molecular mechanisms of cell death signaling and the myriad players involved, including death receptor-ligand systems, BCL-2 family proteins, caspases, inflammasomes, gasdermin, MLKL, RIPK1, A20, and XIAP.