The first Chamber of Chills was a 10-cent horror anthology published bimonthly by Harvey Publications that ran 26 issues (June 1951 - Dec. 1954).

Artists included Bob Powell, Lee Elias, Rudy Palais, Howard Nostrand, and Kremer. Issue 7 is mentioned in Dr. Fredric Wertham's scathing 1954 indictment of comic books Seduction of the Innocent (p. 389). Chamber ceased publication following the Senate Subcommittee on Juvenile Delinquency hearings of 1954. Harvey then began concentrating on titles for young children, including Little Dot and Richie Rich.

Chamber of Chills was formerly Blondie Comics and its numbering begins where Blondie left off (issue 20). The first four issues of Chamber are consequently numbered 21-24. The numbering was reset with the fifth issue February 1952. Chamber of Chills became Chamber of Clues in February 1955 and saw two issues, folding in April 1955.