Nearly a year after the deadly events of City of Red: Part 1, Alfonso Machetti lives in New York with his wife, Cristina, and their baby, Domonic. Not all is perfect, however. After Michael Desantis defeated the Commission, and after his abrupt and mysterious death, a rift divided the five families and in that void the deadly Black Emperor's stepped up to take over all of New York. Amidst the backdrop of war, betrayal inside the Desantis family lurks around every corner. An affair between Bella Desantis-Costa and Joey Ricci threatens to destroy everything. Alfonso decides to help Lila Winters, the woman that murdered Michael Desantis, and then there is Cold Harbor City. The city of snow and ice, of death and corruption. Built on the backs of criminals, Cold Harbor City will finally reveal itself as what it truly is...the City of Red.