Immunoglobulin genetics perspectives from species such as sea lamprey, cattle, marsupial, bat, rat, rabbit, and swine are relevant to antibody design and engineering. These new perspectives find direct application in the cutting-edge areas of antibody design, engineering and therapeutics, antibody-drug conjugates, and novel antibody-based vaccines. Covering significant knowledge that has emerged during the last two decades, this book provides novel antibody phylogenetic perspectives relevant to the development of new antibody-based therapeutics and vaccines.