Dynamic Systems Biology Modeling and Simulation unifies the substance and language of dynamic systems modeling, clarifies the ambiguities in some concepts, and makes it accessible to a wide audience. The book is informed by the author's own modeling efforts and publications over half a century, including novel and previously unpublished features particularly relevant to modeling dynamic systems in biology. These include qualitative theory and methodologies for recognizing dynamical signatures in data using structural (multicompartmental and network) models and graph theory. The biology, biochemistry, and biophysics needed to comprehend the context, goals and biomodeling domain details are included as needed within the chapters. Advanced topics or complex problems not needed on first reading are included as Extensions at the end of chapters and in Appendices.