At the request of the Government-University-Industry Research Roundtable (GUIRR), Shirley Ann Jackson, President of Rensselaer Polytechnic Institute, presents in this brief paper her views of the challenges of the 21st century for the science and engineering workforce. Dr. Jackson identifies factors that she believes are contributing to a declining science and engineering workforce, describes the risks and consequences of this decline, and proposes specific, short-term tasks for universities, industry, and the federal government to strengthen and revitalize the workforce.