During the Depression, the ebullient American entrepreneur Charles Flanagan assembles two thousand runners from all corners of the earth to run from Los Angeles to New York for the prize of $150, 000. Flanagan's Trans-America runners face three thousand miles, across the Mojave desert and the frozen Rockies, running a daily average of fifty miles for three months. The American sports establishment, however, is desperate to crush what it sees as a professional challenge to the 1932 Los Angeles Olympics. Every day is therefore a struggle for survival, for Flanagan himself as well as the runners. Flanagan's Run is an epic tale and a testimony to the strength of the human spirit.