Present paper reviews literature to find out biology of CRP and its role in atherosclerosis, quality of hs-CRP level as a biomarker of risk use of hs-CRP as a tool to initiate statin therapy in CVD and better understand the application of high sensitivity C-reactive protein (hs-CRP) in clinical practice. We highlighted recommendations from societies and important considerations when using hs-CRP to guide treatment decisions in prevention of CVD. The highlights of the monograph on hs-CRP are: . C - reactive protein and high sensitive CRP (hs-CRP): a biomarker of inflammation . Molecular mechanism of CRP in pathogenesis of atherothrombosis and CVD . Interpretations of various trials, guidelines, Class of recommendation (COR), level of evidence (LOE) for use of hs-CRP in CVD risk stratification. . Effect of Lifestyle modifications and dietary supplementations on hs-CRP level.