It's a gem that our awesome publishing company has brought to
life. Now, as part of my job, I get to dive into countless books, and I must
say, this one is an absolute delight. No need for any unnecessary delay, let
me give you a sneak peek into what makes it so worthwhile. Are you ready?
Let's jump right in with the introduction Age-related endocrine disruption
has been linked to cognitive decline and an increased risk of
neurodegenerative illnesses, as evidenced by a growing body of research.
Although oestrogens have long been thought to safeguard brain function, it
was only recently discovered that androgens and luteinizing hormone can
affect cognitive processes by altering how we learn and remember things.
Improving treatment for cognitive impairment linked to the hypothalamicpituitary-
gonadal axis requires a deeper understanding of the underlying
mechanisms. In this article, we highlight the role of reproductive hormones
in preserving brain health and amplifying signalling cascades that lead to
Preface
mental decline. We discuss the endocrine changes that occur with age, their
role in the onset of Alzheimer's disease, and the therapeutic potential of
endocrine manipulation in preventing cognitive decline in the
elderly.Menopause, oophorectomy, oestrogen, testosterone, memory loss,
Alzheimer's disease, and luteinizing hormone are all terms of interest.The
risk of age-related neurodegenerative disorders like Alzheimer's disease
(AD) is increasingly important to think about as the baby boomer
generation ages and life expectancy increases thanks to medical
advancements. By 2050, it's expected that over 13 million people would
have been diagnosed with AD. Dementia is one of the most expensive
diseases, with annual costs of care for people with Alzheimer's disease and
other forms of dementia estimated at over $180 billion in the United States
alone. As the prevalence of neurodegenerative diseases increases, so too
will the emotional, mental, and financial strains placed on those who
provide care for those who have been diagnosed.Amyloid- senile plaques,
neurofibrillary tangles made of aggregated tau, and hippocampal cell loss
are the classic neuropathologies of Alzheimer's disease. Clinically, AD is
distinguished by memory and attention difficulties, which deteriorate into
problems with reasoning, communication, and direction as the disease
advances. Although oxidative stress, inflammation, and neuronal
dysfunction have all been implicated in the development of Alzheimer's
disease, conclusive data explaining disease pathogenesis is lacking, as a
result, we and others have been forced to look beyond these basic
pathologies in search of other molecular cues driving AD pathogenesis.The
effect of gonadal hormones on cognition in the elderly has been the subject
of substantial research. Hormones are known to impact CNS function and
stability.