The novel is about cheating death by rejuvenation. Axa Potter enters a nursing home. A huge freezer is delivered. Four old ladies embark on a quest to escape the inevitable and, using hormones they call Mones, rejuvenate themselves. They become younger. Their adventure takes them from the pine barrens of New Jersey to the southwest to the Caribbean. While most old bags are packing it in, these unripening beauties create a new and heart-warming beginning. A charming cat named Varmint accompanies them on their adventure back through their nine lives.