Motor vehicle crashes (MVCs) contribute large proportion of death and disability globally. In Malaysia, more than 50% of the registered vehicles are motorcycle and it becomes one of the most important forms of personal transportation. The objectives of the study were to determine the factors associated with the severity of injury sustained by motorcyclists' accident as seen in HUSM. The study revealed age more than 50 years (OR=12.87, 95% CI: 1.85, 89.58), no motorcycle license (OR=14.32, 95% CI: 3.85, 53.23), no stressful condition (OR=4.73, 95% CI: 1.64, 13.69) and crash on two-way road (OR=4.78, 95% CI: 1.26, 18.10) increased the odds of getting low score. Accidents on straight roadways (OR=0.24, 95% CI: 0.07, 0.75) or on wet roads (OR=0.09, 95% CI: 0.02, 0.55) and drivers sleeping six to less than nine hours at night prior to accidents (OR=0.11, 95% CI: 0.02, 0.64) reduced the odds for low score. In conclusion, the study identified several modifiable factors and non-modifiable factors associated with injury severity among motorcycle crashes.