In this issue of Clinics in Perinatology, guest editor Dr. David K. Stevenson brings his considerable expertise to the topic of Preterm Birth. The issue of preterm birth is of paramount significance for achieving the United Nations Sustainable Development Goal to end all preventable deaths of newborns and children aged under five years by 2030, this issue of Clinics in Perinatology seeks to provide actionable clinical information for perinatologists who seek to predict and improve outcomes for preterm births.Contains 15 relevant, practice-oriented topics including genomics of preterm birth, predicting preterm birth using proteomics, predicting preterm birth using the microbiome, predicting preterm birth using the immunome, a new taxonomy of preterm birth, and more.Provides in-depth clinical reviews on preterm birth, offering actionable insights for clinical practice.Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.