Long term success in endodontics is not due to single factor but relates to three aspects of treatment, which is termed the ¿Endodontic triad. This includes instrumentation, disinfection and obturation. Instrumentation alone does not ready the canal system for obturation.So, disinfection is key to augmenting the process because it allows for cleaning beyond what might be achieved by root canal instruments alone.Irrigation supports mechanical instrumentation by reducing friction and removing dead and living microbes from the root canal. It is truly said ¿Instruments shape, Irrigants clean. The irrigants used is subject to clinical condition and choice of the clinician.This book will introduce clinicians to various recent advances and techniques in irrigation of the root cana system that might improve the healing outcomes presenting with complex and challenging endodontic conditions