This volume constitutes the proceedings of the 20th IFIP WG 6.11 Conference on e-Business, e-Services, and e-Society, I3E 2021, held in Galway, Ireland, in September 2021.*The total of 57 full and 8 short papers presented in these volumes were carefully reviewed and selected from 141 submissions. The papers are organized in the following topical sections: AI for Digital Transformation and Public Good, AI & Analytics Decision Making, AI Philosophy, Ethics & Governance, Privacy & Transparency in a Digitized Society, Digital Enabled Sustainable Organizations and Societies, Digital Technologies and Organizational Capabilities, Digitized Supply Chains, Customer Behavior and E-business, Blockchain, Information Systems Development, Social Media & Analytics, and Teaching & Learning. *The conference was held virtually due to the COVID-19 pandemic.