This new edition of The European Union and the United States provides an interdisciplinary approach to transatlantic relations and their global contexts. Revised to account for major challenges like Brexit and climate change, it touches on all key facets of EU-US relations in the 21st century, including the political systems of each side, the architecture of the relationship and distinct policy areas such as trade and security. Incorporating speeches, policy documents and key quotations, this new edition is suited to undergraduate and postgraduate students of European integration and external action, US foreign policy, and politics of the West.