Today, neurological disorders, neuromuscular disorders is very important in creating. Including neurological disorders, including Migraine disease.Migraine disease is a neuromuscular disorder that commonly causes A progressive neurodegenerative disease with autosomal dominant inheritance, with the incidence in adulthood, the disease has three abnormal movements, cognitive disorders, psychological disorders known.Migraine disease is caused by genetic mutations, but also epigenetic factors are critical in inducing the disease.In this study we have analyzed 200 people.100 Migraine disease and 100 control group.The gene NOTCH3 analyzed in terms of genetic mutation made.In this study, people who have genetic mutation were targeted, with nervous disorders, Migraine disease.In fact, of all people with Migraine disease.100 Migraine disease had a genetic mutation in the gene NOTCH3 Migraine disease.Any genetic mutations in the target genes control group, did not show.