Passengers boarding the 10.35 train from Manchester Piccadilly to London Euston are bound for work, assignations, reunions, holidays or new starts, with no idea that their journey is about to be brutally curtailed. Holly has just landed her dream job, which should make life a lot easier than it has been, and Jeff is heading for his first ever work interview after months of unemployment. They end up sitting next to each other. Onboard customer service assistant Naz dreams of better things as he collects rubbish from the passengers. And among the others travelling are Nick with his young family who are driving him crazy, pensioner Meg and her partner setting off on a walking holiday and facing an uncertain future, Caroline, run ragged by the competing demands of her stroppy teenage children and her demented mother, and Rhona, unhappy at work and desperate to get home to her small daughter. And in the middle of the carriage sits Saheel, carrying a deadly rucksack . . .