It is more than a century since a connection between the mouth and the rest of the body first appeared in the medical literature. Recent evidence-based literature again strongly suggests that oral health is indicative of systemic health supporting the association between periodontal disease and systemic conditions. This has led to the evolution of a new branch in periodontology, namely Periomedicine. The nature of the association between periodontal disease and systemic diseases is considered bidirectional. Periodontal disease, can be initiated or deteriorated by certain systemic diseases, but also can initiate or deteriorate certain systemic diseases. Periodontal disease can produce numerous changes in systemic health by changing the blood chemistry with raised inflammatory mediators, proteins and lipid in serum. Hyperlipidemia and Thyroid disorders are considered to be related with systemic inflammation.Periodontitis has been found to release inflammatory cytokines to systemic circulation.So, it could be related with these two systemic conditions.The aim is determination of changes in periodontal status obtained by scaling and root planing on serum lipid and thyroid profiles.